绱�(x矛)鑳炲煿椁�(y菐ng)鏄爺鐧�(f膩)鍙婄敓鐢�(ch菐n)CGT钘ュ搧鐨勯棞(gu膩n)閸电挵(hu谩n)绡�(ji茅)锛屽皪CGT鍒跺搧鐨勮唱(zh矛)閲�銆佺┅(w臎n)瀹氭�т互鍙婂畨鍏ㄦ�х瓑鐢�(ch菐n)鐢熷緢澶х殑褰遍熆锛屼笂鏈熷垎浜簡鍕曠墿渚嗘簮鍘熻紨鏂欏湪CGT鐮旂櫦(f膩)鑸囩敓鐢�(ch菐n)涓瓨鍦ㄧ殑棰�(f膿ng)闅�(xi菐n)鍜屽晱椤�锛堟埑閫欓噷鍥為¨锛�锛屼篃鍒嗕韩浜嗙鍏冪敓鐗╃殑妞嶇墿婧愬師杓旀枡鍦–GT涓殑鍎�(y艒u)鍕�锛屾湰鏈熷氨渚嗗垎浜鍏冪敓鐗╃殑鐣�(d膩ng)瀹剁敘(ch菐n)鍝�——妞嶇墿婧愰噸绲勪汉琛�娓呯櫧铔嬬櫧OsrHSA鍦–GT绱�(x矛)鑳炲煿椁�(y菐ng)涓殑鎳�(y墨ng)鐢�銆�
涓�銆佷粈涔堟槸OsrHSA?
浜鸿娓呯櫧铔嬬櫧(Human Serum Albumin,HSA)浣滅偤浜鸿婕夸腑鍚噺鏈�璞愬瘜鐨勮泲鐧�,鏄縺绱�銆佽剛椤炵瓑鐗╄唱(zh矛)鐨勮綁(zhu菐n)閬�(y霉n)杓夐珨锛屽叾涓昏鐢熺悊鍔熻兘鏄(di脿o)绡�(ji茅)琛�婕縫H鍊煎拰缍寔琛�婕挎徊閫忓銆�
OsrHSA鏄鍏冪敓鐗╁埄鐢ㄨ嚜宸辩殑灏堝埄鎶�琛�(sh霉)骞宠嚭—— 姘寸ɑ鑳氫钩绱�(x矛)鑳炵敓鐗╁弽鎳�(y墨ng)鍣ㄩ珮鏁堥噸绲勮泲鐧借唱(zh矛)琛ㄩ仈(d谩)骞宠嚭(OryzHiExp)鍜岄噸绲勮泲鐧界磾鍖栨妧琛�(sh霉)骞宠嚭(OryzPur)鐮旂櫦(f膩)鍜岀敓鐢�(ch菐n)鐨勯噸绲勪汉琛�娓呯櫧铔嬬櫧,涓嶅惈鏈夊嫊鐗╂簮鎴愬垎,涔熺劇浠讳綍琛�娑叉簮鐨勭梾姣掓劅鏌撻ⅷ(f膿ng)闅�(xi菐n)銆傝垏琛�婕夸締婧愮櫧铔嬬櫧(pHSA)鍜岀墰琛�娓呯櫧铔嬬櫧(BSA)鐩告瘮,OsrHSA鍏锋湁鏇撮珮鐨勭磾搴�,鏇村ソ鐨勬壒娆＄┅(w臎n)瀹氭��銆侽srHSA鍦ㄦ按绋昏儦涔充腑琛ㄩ仈(d谩)骞跺劜瀛樺湪姘寸ɑ铔嬬櫧楂斾腑,鑳芥渶澶ч檺搴﹀湴淇濇寔铔嬬櫧璩�(zh矛)鐨勭┅(w臎n)瀹氭�у拰鐢熺墿娲绘�с��
1. OsrHSA鍜岃婕夸締婧愮櫧铔嬬櫧pHSA鐞嗗寲鎬ц唱(zh矛)姣旇純
2. OsrHSA 鑸噋HSA鐨勭祼(ji茅)妲�(g貌u)涓�鑷�
鍦�1.OsrHSA鐨勬暣楂旂祼(ji茅)妲�(g貌u)
鍦撲簩鑹茶瓬娓畾鍑篛srHSA 鐨勫垎瀛愮祼(ji茅)妲�(g貌u)涓昏鐐�α铻烘棆,濡傚湒 1A鎵�绀�,鍜宲HSA涓�妯�,OsrHSA绺介珨绲�(ji茅)妲�(g貌u)鍛堢従(xi脿n)鍑轰竴鍊�(g猫)蹇冨舰褰㈢媭,鐢变笁鍊�(g猫)绲�(ji茅)妲�(g貌u)鍩熺祫鎴�銆傚湒1B涓�,OsrHSA鍜宲HSA鐨勫叐鍊�(g猫)鍒嗗瓙鐨勭祼(ji茅)妲�(g貌u)瀹屽叏涓�鑷�,瀹屽叏閲嶇枈,瑾槑 OsrHSA鍏锋湁鍜宲HSA鐩稿悓鐨勭┖闁撶祼(ji茅)妲�(g貌u)銆�
3. OsrHSA 鍏锋湁鑹ソ鐨勬壒闁撲竴鑷存��
鍦�2 pHSA鑸囦笉鍚屾壒娆srHSA鐨凥PLC绲�(ji茅)鏋�(钘�(l谩n)绶�-pHSA锛屽叾浠栭鑹�-OsrHSA)
鐢⊿EC-HPLC妾㈡脯涓嶅悓鎵规鐨凮srHSA锛岀祼(ji茅)鏋滈’绀哄湒璀滈珮搴﹂噸鍚堬紝涓旂磾搴﹀潎澶т簬99%,鐩稿皪妯�(bi膩o)婧�(zh菙n)鍋忓樊灏忎簬5%锛岃〃鏄庢壒闁撲竴鑷存�фサ楂�銆傚湪2-8鈩冨劜钘�48鍊�(g猫)鏈堝悗锛宲HSA鐩稿皪浜嶰srHSA,鑱氶泦楂斿惈閲忔槑椤洿澶�锛岃〃鏄嶰srHSA闀锋湡绌�(w臎n)瀹氭�ч珮浜巔HSA锛屽劜钘忕┅(w臎n)瀹氭�ц唱(zh矛)閲忕浉杓冧簬pHSA鏇村ソ銆�
4. OsrHSA鑷ㄥ簥鍓嶅畨鍏ㄦ�х爺绌�
浜�銆丱srHSA鍦ㄧ窗(x矛)鑳炲煿椁�(y菐ng)涓殑鎳�(y墨ng)鐢�
澶氶爡(xi脿ng)瀵�(sh铆)椹�(y脿n)鏁�(sh霉)鎿�(j霉)鍙嶉OsrHSA鑳芥湁鏁堜績閫�(j矛n)骞茬窗(x矛)鑳炲娈�锛岀董鎸佸共绱�(x矛)鑳炲舰鎱�(t脿i)鍙婂鍔熻兘鎬э細
鍦�3.鍦╤MSCs涓�锛孫srHSA鍜孊SA浠ュ強琛�娓呭煿椁�(y菐ng)鐨勫娈栨儏娉佸皪姣�
鍦╤MSC鍩归(y菐ng)涓�,涓嶅悓婵冨害鐨凮srHSA鍧囪兘鏈夋晥鐨勪績閫�(j矛n)绱�(x矛)鑳炲娈�,鍚屾績搴︿笅锛孫srHSA灏峂SC鐨勫娈栨晥鏋滈’钁楀劒(y艒u)浜嶣SA锛孫srHSA灏峢MSC鐨勫娈栨晥鏋滆垏鍌崇当(t菕ng)琛�娓呭煿椁�(y菐ng)鍩虹浉姣斿樊涓嶅锛岃鏄嶰srHSA鑳藉彇浠ｅ嫊鐗╄娓呭拰BSA,鐐篽MSC绱�(x矛)鑳炲煿椁�(y菐ng)鎻愪緵鏇村畨鍏ㄧ殑閬告搰銆�
鍦�4 OsrHSA鍜屾棩鏈競鍞畆HSA鍦╥PSC涓殑鍒嗗寲琛ㄧ従(xi脿n)(ALP鏌撹壊鍜屾(bi膩o)瑷樼墿鐔掑厜椤壊)
鑸囨棩鏈競鍞畆HSA鐩告瘮锛�0srHSA鍦╥PS绱�(x矛)鑳炲煿椁�(y菐ng)涓兘鏈夋晥鐨勪績閫�(j矛n)绱�(x矛)鑳炲娈�,缍寔绱�(x矛)鑳炲舰鎱�(t脿i),骞朵笖鑳芥洿鏈夋晥鐨勭董鎸乮PS鐨勫鍔熻兘鎬�銆�
涓�銆丱srHSA鍦ㄧ窗(x矛)鑳炲煿椁�(y菐ng)涓殑鍎�(y艒u)榛�(di菐n)
琛�娓呯櫧铔嬬櫧鍦–GT绱�(x矛)鑳炲煿椁�(y菐ng)涓櫦(f膩)鎻绋敓鐞嗗姛鑳斤細
1. 缍寔鍩归(y菐ng)娑查珨绯荤殑婊查�忓鍜宲H鍊�;
2. 閲戝爆闆㈠瓙铻悎鍔�銆佽剛璩�(zh矛)銆佹皑鍩洪吀浠ュ強鐢熼暦鍥犲瓙鐨勮綁(zhu菐n)閬�(y霉n)杓夐珨;
3. 鑷敱鍩烘竻妤氶櫎鍔�(鎶楁哀鍖栧姛鑳�);
4. 绌�(w臎n)瀹氬姂
涓婃枃瀵�(sh铆)椹�(y脿n)鏁�(sh霉)鎿�(j霉)宸茬稉(j墨ng)璀夋槑浜嗙鍏冪敓鐗╃殑妞嶇墿婧愰噸绲勪汉琛�娓呯櫧铔嬬櫧OsrHSA鍙互淇冮��(j矛n)绱�(x矛)鑳炵敓闀峰拰澧炴畺锛岀董鎸佸共绱�(x矛)鑳炲舰鎱�(t脿i)鍜屽鍔熻兘鎬�锛屽湪绱�(x矛)鑳炲煿椁�(y菐ng)涓櫦(f膩)鎻憲绌嶆サ浣滅敤銆傝垏鍕曠墿鎴栦汉琛�渚嗘簮鐨勮娓呯櫧铔嬬櫧鐩告瘮锛孫srHSA涓嶅瓨鍦ㄤ换浣曞嫊鐗╂簮鎴愪唤锛岀劇浠讳綍鐥呮瘨鎰熸煋棰�(f膿ng)闅�(xi菐n)锛屼笖绂惧厓鐢熺墿閫氶亷瑕�(gu墨)妯″寲绋姘寸ɑ宸茬稉(j墨ng)瀵�(sh铆)鐝�(xi脿n)瓒呯礆鐢�(ch菐n)鑳芥摯(ku貌)澶у寲銆傚彟澶栦粖骞�6鏈堜唤锛岀鍏冪敓鐗╁勾鐢�(ch菐n)10鍣窸srHSA鍘熸恫鐢熺敘(ch菐n)绶氭寮忛枊濮嬫姇鐢�(ch菐n)锛岄�欐(bi膩o)蹇楄憲绂惧厓鐢熺墿鍙互鐐篊GT甯傚牬杓搁�佹洿澶氭洿绌�(w臎n)瀹氱殑妞嶇墿婧愬師杓旀枡锛屽姪鍔涘悇澶т紒妤�(y猫)鎻愬崌鐢�(ch菐n)鍝佺敓鐢�(ch菐n)宸ヨ棟锛屾彁楂樼敘(ch菐n)鍝佸畨鍏ㄥ拰绌�(w臎n)瀹氭�с�傛澶栫鍏冪敓鐗╃殑OsrHSA娉ㄥ皠娑叉鍦ㄥ睍闁嬪叏鐞冨涓績III鏈熻嚚搴婁腑锛屽苟涓擮srHSA宸茬稉(j墨ng)閫氶亷涓湅CDE钘ョ敤杓旀枡鍌欐锛欶20180000305;骞朵笖鍙栧緱FDA鎵规簴(zh菙n)DMF鏂囦欢锛孌MF No.锛�029648(IV鍨�)銆�
鏇村妞嶇墿婧愯娓呯櫧铔嬬櫧瑭崇窗(x矛)璩囨枡姝¤繋鍜ㄨ锛岄浕瑭憋細027-59403932锛屾妧琛�(sh霉)鏀寔鍦ㄧ窔QQ锛�2490959153
姝︽饥绂惧厓鐢熺墿绉戞妧鑲′唤鏈夐檺鍏徃
闆昏┍: 鍏徃绺芥(j墨)锛�027-59403931 鐕熼姺閬�(y霉n)鐕熶腑蹇� 18717109083
鍌崇湡锛�027-59301898
閮电锛� [email protected]
鍦板潃锛氭婕㈡澅婀栨柊鎶�琛�(sh霉)闁嬬櫦(f膩)鍗�(q奴)绁炲ⅸ浜旇矾268铏� 430070
