浜鸿娓呯櫧铔嬬櫧(human serum albumin, HSA)鏄婕夸腑鍚噺鏈�澶氱殑铔嬬櫧璩�(zh矛)锛屾槸涓�绋柈楂斿绲�(ji茅)妲�(g貌u)鍩熷ぇ鍒嗗瓙锛屽叾闈炵硸鍩哄寲鐨勫柈閺堝鑲藉寘鍚�585鍊嬫皑鍩洪吀锛屽垎瀛愰噺鐐�66kD銆傚湪琛�婕夸腑鍏舵績搴︾偤42~55g/L锛岀磩鍗犺婕跨附铔嬬櫧鐨�60%?锛涱媱?/font>HSA鍦ㄤ汉楂斾腑寤ｆ硾鐨勫垎甯冧互鍙�澶氱ó鐢熺悊鍔熻兘锛�闅ㄨ憲鐢熷懡绉戝(xu茅)鐮旂┒鐨勬繁鍏�锛屽垎瀛愮敓鐗╁(xu茅)鐮旂┒鐨勮垐璧�锛�HSA瓒婁締瓒婂鐨勭敓鐗╂椿鎬у姛鑳借闁嬬櫦(f膩)鍜屽埄鐢紝鎴愮偤鐢熺墿瀛�(xu茅)鐮旂┒闂�(gu膩n)閸垫�ц泲鐧借唱(zh矛)銆�
鍦�1锛�HSA铔嬬櫧绲�(ji茅)妲�(g貌u)绀烘剰鍦�
- HSA鑸囪棩鐗╄級楂�
HSA鍏锋湁鍎�(y艒u)绉�鐨�閰嶉珨绲�(ji茅)鍚堣兘鍔�锛�鍙�鐐轰竴浜涢厤楂旀彁渚涗唬璎濅慨椋�锛�闄嶄綆娼涘湪姣掔礌姣掓��锛岀偤浜洪珨琛�婕挎彁渚�鎶楁哀鍖栫殑鑳藉姏锛�HSA鍏锋湁瑕按鎬�銆�鐒″厤鐤師鎬�銆�鐢熺墿鐩�瀹规�уソ銆�鍖栧(xu茅)鎬ц兘绌�(w臎n)瀹�銆�鍏锋湁澶氱ó钘ョ墿绲�(ji茅)鍚堜綅榛炵瓑鍎�(y艒u)榛�锛屽洜鑰�琚獚(r猫n)鐐烘槸涓�绋潪甯哥悊鎯崇殑钘ョ墿杓夐珨锛�1锛�锛�琚唬娉涙噳(y墨ng)鐢ㄤ簬灏忓垎瀛愬寲钘�銆佸鑲�銆佽泲鐧�銆佹牳閰哥瓑澶氱ó娌荤檪钘ョ墿鐨勯仦閫�銆�HSA鏃㈠彲閫氶亷鑸囨不鐧傝棩鐗╁叡鍍圭祼(ji茅)鍚�銆�闈炲叡鍍�绲�(ji茅)鍚堟垨鍩哄洜铻嶅悎鐨勬柟寮�杓夎棩锛屼篃鍙互鍒跺倷鎴愮磵绫崇矑瀛愯級钘�锛屽苟涓�HSA杓夎棩楂旂郴鍏锋湁鍙敓鐗╅檷瑙ｃ�侀潪鍏嶇柅鍘熸��銆佸崐琛版湡闀风瓑鐗归粸銆�杩戝勾渚�HSA瓒婁締瓒婂鐨勮鐮旂┒鐢ㄤ締浣滅偤鍚勯钘ョ墿鐨勮級楂�锛屽绋棩鐗╅鍨嬪凡缍�(j墨ng)鐛叉壒涓婂競銆�
琛�1宸茬嵅鎵逛笂甯傜殑鍩轰簬浜鸿娓呯櫧铔嬬櫧鐨勮棩鐗╅仦閫佺郴绲�(t菕ng)锛堟憳鑷�闄抽噸绛�锛�2022[2]锛�
|
钘ョ墿鍚嶇ū |
鐮旂櫦(f膩)姗�(j墨)妲�(g貌u) |
鎻忚堪 |
閬╂噳(y墨ng)鐧�鎴栫敤閫� |
鐛叉壒鏅傞枔 |
|
Levemir® 锛�NN304锛� |
Novo Nordisk |
浜鸿儼宄剁礌-鑴傝偑閰歌鐢熺墿鑸囬珨鍏�(n猫i)鐨�HSA闈炲叡鍍圭祼(ji茅)鍚� |
1 鍨嬪拰2 鍨嬬硸灏跨梾 |
2004(EMA):2005(FDA) |
|
Abraxane® 锛�ABI-007锛� |
Celgene锛�Abraxis Bioscience锛�Astrazeneca |
HSA绲�(ji茅)鍚堝瀷绱潐閱� |
杞�(zhu菐n)绉绘�т钩鑵虹檶锛岄潪灏忕窗(x矛)鑳炶偤鐧�锛岃儼鑵虹檶 |
2005(FDA) |
|
Vasovist® |
Beyer Schering |
HSA鑸囬嚀闈炲叡鍍圭祼(ji茅)鍚� |
纾佸叡鎸垚鍍�(MRI)閫犲奖鍔� |
2008(FDA) |
|
Victoza® 锛�Liraglutide锛� |
Novo Nordisk |
鑳伴珮琛�绯栫礌妯ｈ偨-1(GLP-1)-鑴傝偑閰歌鐢熺墿鑸囬珨鍏�(n猫i)鐨� HSA闈炲叡鍍圭祼(ji茅)鍚� |
2鍨嬬硸灏跨梾 |
2009(EMA):2010(FDA) |
|
Eperzan® 锛�Albiglutide锛� |
GlaxoSmithKline |
GLP-1鑸�HSA鍩哄洜铻嶅悎 |
2鍨嬬硸灏跨梾 |
2014(FDA) |
|
Tresiba® 锛�NN1250锛� |
Novo Nordisk |
浜鸿儼宄剁礌-鑴傝偑閰歌鐢熺墿鑸囬珨鍏�(n猫i)鐨�HSA 闈炲叡鍍圭祼(ji茅)鍚� |
1鍨嬪拰2鍨嬬硸灏跨梾 |
2015(FDA) |
|
Idelvion |
CSL Behring GmbH
|
鍑濊鍥犲瓙鈪�鑸囬噸绲� HSA 鍩哄洜铻嶅悎 |
B 鍨嬭鍙嬬梾 |
2016(FDA);2020(EMA) |
|
Fyarro™ |
Aadi Bioscience |
HSA 绲�(ji茅)鍚堝瀷闆峰笗闇夌礌 |
琛�绠″懆鍦嶄笂鐨ǎ绱�(x矛)鑳炵槫 |
2021(FDA) |
鍦ㄨ叓鐦ょ殑娌荤檪涓�锛屽埄鐢�HSA杓夎棩鍙互椤憲鎻愰珮鑵槫绱�(x矛)鑳炰腑钘ョ墿鐨勫垎甯冿紝鎻愰珮钘ョ墿闈跺悜鎬�銆傛澶栵紝HSA閭勫叿鏈夊叾浠�鍎�(y艒u)鍕�锛�1锛�鑸囪棩鐗╄瀺鍚堝彲寤堕暦鑲介钘ョ墿鐨勫崐琛版湡锛屾笡灏戠敤钘ュ姂閲忓拰钘ョ墿鍓綔鐢紝娓涘皯鎮ｈ�呯敤钘ユ鏁�(sh霉)锛�2锛�鎻愰珮榛忚泲鐧界殑鍒嗘硨閲�锛岀敤浜庢淮鐪兼恫娌荤檪骞茬溂鐧�锛�3锛�鑸囪啝鍘熻泲鐧界祼(ji茅)鍚堝埗鎴愭琛�鏉愭枡锛屼笉鍍呰兘绲�(ji茅)鍚�銆侀亱(y霉n)杓歌棩鐗�锛岄倓浣挎琛�鏉愭枡澧炲姞浜嗕慨寰�(f霉)绲勭箶鍔熻兘鐨勪綔鐢�锛�4锛�鑸囪仛涔欎簩閱囧埗鎴愭按鍑濊啝锛屽彲鐢ㄤ簬澶栫鎵嬭(sh霉)涓紱5锛�鑸囩矑绱�(x矛)鑳為泦钀藉埡婵�鍥犲瓙褰㈡垚铻嶅悎铔嬬櫧锛屽彲澶уぇ寤堕暦鍏跺崐琛版湡锛�3-5锛�銆�Ssu-Hsueh Tseng,绛�[6]灏卞牨閬撲簡涓�绋櫧铔嬬櫧鑸�骞叉摼绱�β鐨勮瀺鍚堣泲鐧�锛岃垏鎶楀師澶氳偨HPVE7灞曠従(xi脿n)鍑哄劒(y艒u)绉�鐨勮叓鐦ょ敓闀锋姂鍒惰兘鍔�锛�鍚屾檪澶уぇ寤堕暦浜嗚棩鐗╃殑鍦ㄩ珨鍏�(n猫i)鐨�鏈夋晥鏅傞枔锛岄仈(d谩)鍒伴暦鏅傞枔鎶戝埗鑵槫鐧�(f膩)鑲茬殑浣滅敤锛堝湒1锛�銆�
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琛�2 涓湅琛�娑插埗鍝佽妤�(y猫)鐩搁棞(gu膩n)鏀跨瓥
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鐧�(f膩)甯冩檪闁� |
鐧�(f膩)甯冩(j墨)妲�(g貌u) |
鏀跨瓥鍚嶇ū |
鏀跨瓥鍏�(n猫i)瀹� |
|
2016骞�4鏈� |
鍚夋灄鐪佷汉姘戞斂搴� |
銆婇棞(gu膩n)浜庢帹閫�(j矛n)閱�(y墨)钘ュ仴搴风敘(ch菐n)鍝佺櫦(f膩)灞曠殑瀵︽柦鎰忚銆� |
鍔犲ぇ鍔涘害鎺ㄩ��(j矛n)涓棩鍜岀敓鐗╄棩鍘熺爺钘�銆佺敓鐗╄棩鍜屽寲鍙楄棩棣栦豢钘ョ瓑鍓�(chu脿ng)鏂拌棩鐗╃殑闁嬬櫦(f膩)銆�閲嶉粸鏀寔娉ㄥ皠鐢ㄩ噸绲勪汉琛�鐧借泲鐧�鍠厠闅嗘姉楂旈樋閬�(d谩)涓嶇瓑“閲嶇澶х磩”鐨勫壍(chu脿ng)鍒惰垏鐢�(ch菐n)妤�(y猫)鍖�銆傚皪娉ㄥ皠鐢ㄩ噸绲勪汉琛�鐧借泲鐧�銆佸柈鍏嬮殕鎶楅珨闃块仈(d谩)鏈ㄧ瓑“閲嶇澶ц棩”鐨勫壍(chu脿ng)鍒惰垏鐢�(ch菐n)妤�(y猫)鍖栵紝瀵︾従(xi脿n)鐢�(ch菐n)妤�(y猫)鍖栧悗绲︿簣100-300钀厓鏀寔銆� |
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2021骞�4鏈� |
灞辫タ鐪佷汉姘戞斂搴� |
銆婇棞(gu膩n)浜庡嵃鐧�(f膩)灞辫タ鐪�“鍗佸洓浜�”鏈締鐢�(ch菐n)妤�(y猫)鐧�(f膩)灞曡(gu墨)鍔冪殑閫氱煡銆� |
鍔犻�熺櫦(f膩)灞曞寘鎷汉琛�鐧借泲鐧藉湪鍏�(n猫i)鐨勭敓鐗╅啱(y墨)钘ョ敘(ch菐n)鍝�锛屼績閫�(j矛n)鐢�(ch菐n)鍝佸寲銆侀泦鑱氬寲銆佸湅闅涘寲鐧�(f膩)灞� |
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2021骞�11鏈� |
姹熻タ鐪佸伐妤�(y猫)鍜屼俊鎭寲寤� |
銆婇棞(gu膩n)浜庡嵃鐧�(f膩)姹熻タ鐪�“鍗佸洓浜�”鐢�(ch菐n)妤�(y猫)鎶�琛�(sh霉)鍓�(chu脿ng)鏂扮櫦(f膩)灞曡(gu墨)鍔冪殑閫氱煡銆� |
灏囦汉琛�鐧借泲鐧藉垪鐐虹敓鐗╅啱(y墨)钘ョ敘(ch菐n)妤�(y猫)绉戞妧鐨勯噸榛炵櫦(f膩)灞曟柟鍚戜箣涓�銆傝仛鐒﹀偝鎵跨櫦(f膩)灞曚腑閱�(y墨)钘�銆佹彁鍗囩櫦(f膩)灞曞寲瀛�(xu茅)钘�銆佺獊鐮寸櫦(f膩)灞曠敓鐗╄棩銆佸壍(chu脿ng)鏂扮櫦(f膩)灞曢啱(y墨)鐧傚櫒姊�锛屽姞蹇缓绔嬪壍(chu脿ng)鏂伴﹨(q奴)鍕曘�佺祼(ji茅)妲�(g貌u)鍎�(y艒u)鑹�銆佺壒鑹查鏄庣殑閱�(y墨)钘ョ敘(ch菐n)妤�(y猫)楂旂郴锛屽舰鎴愪互楂樺搧璩�(zh矛)涓啱(y墨)钘�銆佸寲瀛�(xu茅)钘�銆佺敓鐗╅啱(y墨)钘�銆侀啱(y墨)鐧傚櫒姊扮偤鏀拹鐨勯啱(y墨)钘ョ敘(ch菐n)妤�(y猫)澶ф牸灞�锛屼績閫�(j矛n)閱�(y墨)钘ョ敘(ch菐n)妤�(y猫)鑸囨暩(sh霉)瀛楃稉(j墨ng)婵�(j矛)铻嶅悎鐧�(f膩)灞曘�� |
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2021骞�11鏈� |
娌冲寳鐪佹斂搴滆睛鍏怀 |
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2022骞�2鏈� |
婀栧寳鐪佺稉(j墨ng)婵�(j矛)鍜屼俊鎭寲寤� |
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2022骞�3鏈� |
浜戝崡鐪佷汉姘戞斂搴滆睛鍏怀 |
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- Fanali G, di Masi A, Trezza V, Marino M, Fasano M, Ascenzi P. Human serum albumin: from bench to bedside. Mol Aspects Med. 2012 Jun;33(3):209-90.
- 闄抽噸, 閲庢叾鏉�, 鍚抽對鎱�. 鍩轰簬浜鸿娓呯櫧铔嬬櫧鐨勮棩鐗╅仦閫佺郴绲�(t菕ng)鐮旂┒閫�(j矛n)灞�[J]. 钘ュ(xu茅)閫�(j矛n)灞�, 2022, 46(7):7.
- 寮靛缓杌�锛岄珮绶�锛屽濠夌懢. 鐧借泲鐧戒綔鐐鸿棩鐗╄級楂旂殑鐮旂┒锛�J锛�. 鍖栧(xu茅)閫�(j矛n)灞曪紝2011锛�23锛�8锛夛細1747-1754.
- 瀵屽窎锛岄Μ閲戠幉锛屽楹�锛岀瓑. 閲嶇祫浜鸿娓呯櫧铔嬬櫧/骞叉摼绱�α2a铻嶅悎铔嬬櫧鐨勮棩鏁堝(xu茅)銆佽棩浠ｅ嫊鍔涘(xu茅)鍙婂畨鍏ㄦ�ц⿻鍍癸蓟J锛�. 涓湅閱�(y墨)钘ョ敓鐗╂妧琛�(sh霉)锛�2012锛�7锛�6锛夛細401-411.
- 瀛ｇ宄�锛岀煶鑾夛紝閯ф剰杓�. 鐧借泲鐧界磵绫崇矑钘ョ墿鍌抽仦绯荤当(t菕ng)鐨勭爺绌堕��(j矛n)灞曪蓟J锛�. 娌堥櫧钘ョ澶у(xu茅)瀛�(xu茅)鍫�锛�2010锛�27锛�12锛夛細968-978.
- Tseng SH, Cheng MA, Farmer E, et al. Albumin and interferon-β fusion protein serves as an effective vaccine adjuvant to enhance antigen-specific CD8+ T cell-mediated antitumor immunity. J Immunother Cancer. 2022;10(4):e00434
姝︽饥绂惧厓鐢熺墿绉戞妧鑲′唤鏈夐檺鍏徃
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